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At CNTE Lab, we are committed to advancing the field of supramolecular chemistry and translating our research into meaningful treatments that can improve the lives of patients around the world. We invite you to explore our publication page to learn more about our groundbreaking research and its potential impact on the future of medicine.

The list of publications is given below:

 2023     Fontana F, Carlino C, Malik A, Gelain F (2023) Morphoscanner2.0: A new python module for analysis of molecular dynamics simulations. PLoS ONE 18(4): e0284307.

2023      Marchini A, Ciulla MG, Antonioli B, Agnoli A, Bovio U, Visnoviz V, Bertuzzi F and Gelain F (2023) Long-term cultures of human pancreatic islets in self-assembling peptides hydrogels. Front. Bioeng. Biotechnol. 11:1105157. doi: 10.3389/fbioe.2023.1105157 

2023     Buzzaccaro S, Ruzzi V, Gelain F, Piazza R. A Light Scattering Investigation of Enzymatic Gelation in Self-Assembling Peptides. Gels. 2023; 9(4):347.

2023    Marchini A, Ciulla MG, Antonioli B, Agnoli A, Bovio U, Visnoviz V, Bertuzzi F, Gelain F “Long-term cultures of human pancreatic islets in self-assembling peptides hydrogels” Frontiers in Bioengineering and Biotechnology 11:1105157. doi: 10.3389/fbioe.2023.1105157

2023    Ciulla MG and Gelain F “Structure-Activity Relationships of Antibacterial Peptides” Microbial Biotechnology 16 (4), 757-777 doi: 10.1111/1751-7915.14213 

2022    Profico DC, Gelati M, Ferrari D, Sgaravizzi G, Ricciolini C, Projetti-Pensi M, Muzi G,   Cajola L, Copetti M, Ciusani E, Pugliese R, Gelain F, Vescovi AL “Human neural stem cell-based drug products: clinical and non-clinical characterization” International Journal of Molecular Sciences 23: 13425. doi: 10.3390/ijms232113425 

2022    Fontana F and Gelain F “Modeling of supramolecular biopolymers: leading the in-silico revolution of tissue engineering and nanomedicine” Nanotechnology Reviews 11: 2965-2996. doi: 10.1515/ntrev-2022-0455 


2022    Ciulla MG, Pugliese R, Gelain F “Boosted Cross-Linking and Characterization of 
High-Performing Self-Assembling Peptides” Nanomaterials 12(3):320. doi: 10.3390/nano12030320 


2022    Pugliese R, Montuori M, Gelain F “Bioinspired Photo-Crosslinkable Self-Assembling Peptide with pH-Switchable “On−Off” Luminescence” Nanoscale Advances 4: 447-456. doi: 10.1039/d1na00688f

2022    Pugliese R, Gelain F “Programmable Stiffness and Stress–Relaxation of Cross-linked Self-Assembling Peptide Hydrogels” Journal of Applied Polymer Science 139(9): 51759. doi: 10.1002/app.51759

2021    Pugliese R, Gelain F, Arnoldi A, Lammi C “Chemistry and functional roles of food protein hydrogels”, Food Proteins and Peptides: Emerging Biofunctions, Food and Biomaterial Applications. Royal Society of Chemistry, London, UK. 157-172. Book Chapter doi: 10.1039/9781839163425-00157

2021    Nobile MS, Fontana F, Manzoni L, Cazzaniga P, Mauri G, Saracino G, Besozzi D, Gelain F “HyperBeta: a novel tool for the investigation of     the kinetic behavior of self-assembling peptides” Scientific Reports 11(1), 1-10 doi: 10.1038/s41598-021-87087-0


2021    Marchini A, Gelain F “Synthetic scaffolds for 3D cell cultures and organoids: applications in regenerative medicine” Critical Reviews in Biotechnology 1-19. doi:10.1080/07388551.2021.1932716


2021    Gelain F, Luo Z, Rioult M, Zhang S “Self-assembling peptide scaffolds in the clinic” NPJ Regenerative Medicine 6(1): 9 doi: 10.1038/s41536-020-00116-w.


2021    Raspa A, Carminati L, Pugliese R, Fontana F, Gelain F “Self-assembling peptide hydrogels for the stabilization and sustained release of active Chondroitinase ABC in vitro and in spinal cord injuries” Journal of Controlled Release 330: 1208-1219 doi: 10.1016/j.jconrel.2020.11.027. 

2020    Raspa A, Gelain F “Mimicking extracellular matrix via engineered nanostructured biomaterials for neural repair” Current Neuropharmacology 19 (12), 2110-2124. doi: 10.2174/ 1570159X18666201111111102.

2020    Gelain F, Zhongli L, Zhang S "Self-assembling Peptide EAK16 and RADA16 Nanofiber Scaffold Hydrogel” Chemical Reviews 120 (24): 13434-13460. doi: 10.1021/acs.chemrev.0c00690

2020    Lau CYJ, Fontana F, Mandemaker L, Wezendonk D, Vermeer B, Bonvin A, Vries R, Zhang H, Remaut K, Dikkenberg J, Medeiros-Silva J, Hassan A, Perrone B, Kuemmerle R, Gelain F, Hennink W, Weingarth M, Mastrobattista E “Control over the fibrillization yield by varying the oligomeric nucleation propensities of self-assembling peptides” Communications Chemistry 3 (1): 1-10. doi: 10.1038/s42004-020-00417-7

2020    Pugliese R, Moretti L, Maiuri M, Romanazzi T, Cerullo G, Gelain F “Superior Mechanical and Optical Properties of a Heterogeneous Library of Cross-Linked Biomimetic Self-Assembling Peptides” Materials & Design 194 doi: 10.1016/j.matdes.2020.108901

2020    Pugliese R, Gelain F “Cross-linked Self-Assembling Peptides and Their Post-Assembly 
Functionalization via One-pot and In Situ Gelation System.” International Journal of Molecular Sciences 21 (12): 1-15 doi: 10.3390/ijms21124261

2020    Marchini A, Favoino C, Gelain F “Multi-functionalized self-assembling peptides as reproducible 3D cell culture systems enabling differentiation and survival of various human neural stem cell lines.” Frontiers in Neuroscience 14: art.413 doi: 10.3389/fnins.2020.00413

2020    Dellafiora L, Pugliese R, Bollati C, Gelain F, Galaverna G, Arnoldi Anna, Lammi C “Bottom up” strategy for the identification of novel soybean peptides with ACE-inhibitory activity" Journal of Agricultural and Food Chemistry 68 (7): 2082-2090 doi: 10.1021/acs.jafc.9b07361

2020    Fontana F, Gelain F “Probing mechanical properties and failure mechanisms of fibrils of self-assembling peptides” Nanoscale Advances 2: 190-198. doi: 10.1039/c9na00621d


2020     Pugliese R, Gelain F “Characterization of Elastic, Thermo-Responsive, Self-Healable Supramolecular Hydrogel made of Self-Assembly Peptides and Guar Gum” Materials & Design 186, doi: 10.1016/j.matdes.2019.108370

2019    Jekhmane S, Prachar M, Pugliese R, Fontana F, Medeiros-Silva J, Gelain F, Weingarth M “Design parameters of tissue engineering scaffolds at atomic scale” Angewandte Chemie Int. Ed. 58: 2-11. doi: 10.1002/anie.201907880

2019    Pugliese R, Bollati C, Gelain F, Arnoldi A, Lammi C "A Supramolecular Approach to develop new Soybean and Lupin Peptide Nanogels with enhanced DPP-IV Inhibitory Activity" Journal of Agricultural and Food Chemistry 67 (13): 3615-3623. doi: 10.1021/acs.jafc.8b07264

2019    Marchini A, Raspa A, Pugliese R, Abd El Malek M, Pastori V, Lecchi M, Vescovi AL, Gelain F “Multi-functionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries” Proc Natl Acad Sci U S A. 116 (15):7483-7492. doi: 10.1073/pnas.1818392116

2019    Lammi C, Bollati C, Gelain F, Arnoldi A, Pugliese R “Enhancement of the stability and anti-DPPIV activity of hempseed hydrolysates through self-assembling peptide-based hydrogels” Frontiers in Chemistry 6, 670. doi: 10.3389/fchem.2018.00670

2019    Pugliese R, Maleki M, Zuckermann RN, Gelain F “Self-assembling peptides cross-linked with Genipin: resilient hydrogels and self-standing electrospun scaffolds for tissue engineering applications” Biomaterials Science 7, 76-91. doi: 10.1039/C8BM00825F.

2018    Saracino G, Fontana F, Jekhmane S, Silva JM, Weingarth M, Gelain F “Elucidating self-assembling peptide aggregation via Morphoscanner: a new tool for protein-peptide structural characterization” Advanced Science 5 (8): 1800471 doi: 10.1002/advs.201800471.

2018    Raspa A, Bolla E, Cuscona C, Gelain F “Feasible stabilization of chondroitinase abc enables reduced astrogliosis in a chronic model of spinal cord injury” CNS Neuroscience & Therapeutics 25 (1): 86-100. doi: 10.1111/cns.12984.

2018    Pugliese R, Marchini A, Saracino G, Gelain F “Functionalization of self-assembling peptides for neural tissue engineering” Self-Assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine. Elsevier, Amsterdam, NL: 475-493. Book Chapter.

2017     Pugliese R, Fontana F, Marchini A, Gelain F “Branched peptides integrate into self-assembled nanostructures and enhance biomechanics of peptidic hydrogels” Acta Biomaterialia. 66: 258-271 doi: 10.1016/j.actbio.2017.11.026.

2017    Pugliese R, Marchini A, Saracino GA, Zuckermann RN, Gelain F “Cross-linked self-assembling peptide scaffolds” Nano Research. 11(1): 586-602. doi: 10.1007/s12274-017-1834-6.

2017    Maleki M, Natalello A, Pugliese R, Gelain F “Fabrication of nanofibrous electrospun scaffolds from a heterogeneous library of co- and self-assembling peptides” Acta Biomaterialia. 51: 268-278. doi: 10.1016/j.actbio.2017.01.038.

2017    Pugliese R and Gelain F “Peptidic biomaterials: from self-assembling to regenerative medicine” Trends in Biotechnology. 35(2): 145-158. doi: 10.1016/j.tibtech.2016.09.004.

2016    Raspa A, Marchini A, Vasita R, Maleki M, Pugliese R, Mauri M, Gelain F “A biocompatibility study of new nanofibrous scaffolds for nervous regeneration” Nanoscale 8(1): 253-265. doi: 10.1039/c5nr03698d.

2016    Raspa A, Pugliese R, Maleki M, Gelain F “Recent therapeutic approaches for spinal cord injury” Biotechnology & Bioengineering 113(2): 253-259. doi: 10.1002/bit.25689.

2014    Bradshaw M, Ho D, Fear MW, Gelain F, Wood FM, Iyer KS “Designer self-assembling hydrogel scaffolds can impact skin cell proliferation and migration.”  Scientific Reports 4:6903 doi: 10.1038/srep06903.

2014    Raspa A, Saracino G, Pugliese R, Silva D, Cigognini D, Vescovi A, Gelain F “Complementary Co-Assembling Peptides: from in silico studies to in vivo application.” Advanced Functional Materials 40(24): 6317-6328. doi: 10.1002/adfm.201400956.

2014    Cigognini D, Silva D, Paloppi S, Gelain F “Evaluation of mechanical properties and therapeutic effect of injectable self-assembling hydrogels for spinal cord injury.” Journal of Biomedical Nanotechnology 10(2): 309-323. doi: 10.1166/jbn.2014.1759.

2013    Saracino G and Gelain F “Modeling and analysis of early aggregation events of BMHP1-derived self-assembling peptides.” Journal of Biomolecular Structure & Dynamics 32(5): 759-775. doi: 10.1080/07391102.2013.790848.

2013    Caprini A, Silva D, Zanoni I, Cunha C, Volontè C, Vescovi A, Gelain F “A Novel Bioactive Peptide: Assessing its Activity Over Murine Neural Stem Cells and its Potential for Neural Tissue Engineering.”  New Biotechnology 30(5): 552-562. doi: 10.1016/j.nbt.2013.03.005.

2013    Cunha C, Panseri S, Gelain F. Engineering of a 3D Nanostructured Scaffold Made of Functionalized Self-Assembling Peptides and Encapsulated Neural Stem Cells. Methods in Molecular Biology. 2013 Clifton, NJ: Book Chapter doi: 10.1007/7651_2012_2.

2013    Vasita R, Gelain F. “Core-sheath Fibres for Regenerative Medicine” Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering. Wiley-Scrivener Publishing, Beverly: 493-533. Book Chapter. 

2013    Silva D, Natalello A, Sanii B, Vasita R, Saracino GAA, Zuckermann RN, Doglia SM, Gelain F “Synthesis and Characterization of Designed BMHP1-Derived Self-Assembling Peptides for tissue engineering applications.” Nanoscale 5(2):704-718. doi: 10.1039/c2nr32656f.

2013    Saracino GAA, Cigognini D, Silva D, Caprini A, Gelain F “Nanomaterials design and tests for neural tissue engineering.” Chemical Society Reviews 42(1):225-262.

2012    Gelain F, Cigognini D, Caprini A, Silva D, Colleoni B, Donegá B, Antonini S, Cohen BE, Vescovi A. “New Bioactive Motifs and Their Use in Functionalized Self-Assembling Peptides for NSC Differentiation and Neural Tissue Engineering” Nanoscale 4(9):2946-2957.

2012    Zhang S, Yokoi H, Gelain F, Horii A “Designer Self-Assembling Peptide Nanofiber Scaffolds” Nanotechnology for Biology and Medicine: At the Building Block Level, Springer Science/Business Media Press, New York City: 123-147. Book Chapter

2011    Cigognini D, Satta A, Colleoni B, Silva D, Donega’ M, Antonini S, Gelain F “Evaluation of Early and Late Effects into the Acute Spinal Cord Injury of an Injectable Functionalized Self-assembling Scaffold”. PLoS ONE 6(5):1-15.

2011    Cunha C, Panseri S, Villa O, Silva D, Gelain F “3D culture of adult mouse neural stem cells within different functionalized self-assembling peptide scaffolds” International Journal of Nanomedicine 6: 943-955.


2011    Gelain F, Silva D, Caprini A, Villa O, Taraballi F, Natalello A, Nam KT, Doglia SM, Vescovi A “BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications.” ACS Nano 5(3):1845-59.

2011    Gelain F, Panseri S, Antonini S, Cunha C, Donega M, Lowery J, Taraballi F, Cerri G, Montagna M, Baldissera F, Vescovi A “Transplantation of nanostructured composite scaffolds neuro-prosthetics results in tissue reconstruction, axonal regeneration and neurological recovery in the chronically injured rat spinal cord.” ACS Nano 5(1): 227-236.

2010    Gelain F, Unsworth L, Zhang S “Slow and sustained release of active cytokines from self-assembling peptide scaffolds” Journal of Controlled Release 145(3):231-239.

2010    Taraballi F, Natalello A, Campione M, Doglia SM, Paleari A, Gelain F “Glycine-spacers influence over functional motif exposure and self-assembling propensity of functionalized peptides” Frontiers in Neuroengineering 3:1-9.

2009    Antonini S, Vescovi A, Gelain F “Stem cells and biomaterials: the tissue engineering approach” Stem Cells & Regenerative Medicine, Springer/Humana Press, New York City. Book Chapter

2009     Gelain F, Wang X, Horii A, Hucknall A, Koutsopoulos S, Zhang S “Designer self-assembling peptides scaffolds for 3-dimensional tissue cell cultures” Methods in Bioengineering, Artech House Press, Boston: 59-81. Book Chapter

2009    Lowery J, Panseri S, Cunha C, Gelain F “Electrospinning for Tissue Engineering Applications” Electrospun Nanofibers Research: Recent Developments, NOVA Science Publishers, Hauppauge.: 1-18. Book Chapter

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