Publications
At CNTE Lab, we are committed to advancing the field of supramolecular chemistry and translating our research into meaningful treatments that can improve the lives of patients around the world. We invite you to explore our publication page to learn more about our groundbreaking research and its potential impact on the future of medicine.
The list of publications is given below:
2023 Fontana F, Carlino C, Malik A, Gelain F (2023) Morphoscanner2.0: A new python module for analysis of molecular dynamics simulations. PLoS ONE 18(4): e0284307. https://doi.org/10.1371/journal.pone.0284307
2023 Marchini A, Ciulla MG, Antonioli B, Agnoli A, Bovio U, Visnoviz V, Bertuzzi F and Gelain F (2023) Long-term cultures of human pancreatic islets in self-assembling peptides hydrogels. Front. Bioeng. Biotechnol. 11:1105157. doi: 10.3389/fbioe.2023.1105157
2023 Buzzaccaro S, Ruzzi V, Gelain F, Piazza R. A Light Scattering Investigation of Enzymatic Gelation in Self-Assembling Peptides. Gels. 2023; 9(4):347. https://doi.org/10.3390/gels9040347
2023 Marchini A, Ciulla MG, Antonioli B, Agnoli A, Bovio U, Visnoviz V, Bertuzzi F, Gelain F “Long-term cultures of human pancreatic islets in self-assembling peptides hydrogels” Frontiers in Bioengineering and Biotechnology 11:1105157. doi: 10.3389/fbioe.2023.1105157
2023 Ciulla MG and Gelain F “Structure-Activity Relationships of Antibacterial Peptides” Microbial Biotechnology 16 (4), 757-777 doi: 10.1111/1751-7915.14213
2022 Profico DC, Gelati M, Ferrari D, Sgaravizzi G, Ricciolini C, Projetti-Pensi M, Muzi G, Cajola L, Copetti M, Ciusani E, Pugliese R, Gelain F, Vescovi AL “Human neural stem cell-based drug products: clinical and non-clinical characterization” International Journal of Molecular Sciences 23: 13425. doi: 10.3390/ijms232113425
2022 Fontana F and Gelain F “Modeling of supramolecular biopolymers: leading the in-silico revolution of tissue engineering and nanomedicine” Nanotechnology Reviews 11: 2965-2996. doi: 10.1515/ntrev-2022-0455
2022 Ciulla MG, Pugliese R, Gelain F “Boosted Cross-Linking and Characterization of
High-Performing Self-Assembling Peptides” Nanomaterials 12(3):320. doi: 10.3390/nano12030320
2022 Pugliese R, Montuori M, Gelain F “Bioinspired Photo-Crosslinkable Self-Assembling Peptide with pH-Switchable “On−Off” Luminescence” Nanoscale Advances 4: 447-456. doi: 10.1039/d1na00688f
2022 Pugliese R, Gelain F “Programmable Stiffness and Stress–Relaxation of Cross-linked Self-Assembling Peptide Hydrogels” Journal of Applied Polymer Science 139(9): 51759. doi: 10.1002/app.51759
2021 Pugliese R, Gelain F, Arnoldi A, Lammi C “Chemistry and functional roles of food protein hydrogels”, Food Proteins and Peptides: Emerging Biofunctions, Food and Biomaterial Applications. Royal Society of Chemistry, London, UK. 157-172. Book Chapter doi: 10.1039/9781839163425-00157
2021 Nobile MS, Fontana F, Manzoni L, Cazzaniga P, Mauri G, Saracino G, Besozzi D, Gelain F “HyperBeta: a novel tool for the investigation of the kinetic behavior of self-assembling peptides” Scientific Reports 11(1), 1-10 doi: 10.1038/s41598-021-87087-0
2021 Marchini A, Gelain F “Synthetic scaffolds for 3D cell cultures and organoids: applications in regenerative medicine” Critical Reviews in Biotechnology 1-19. doi:10.1080/07388551.2021.1932716
2021 Gelain F, Luo Z, Rioult M, Zhang S “Self-assembling peptide scaffolds in the clinic” NPJ Regenerative Medicine 6(1): 9 doi: 10.1038/s41536-020-00116-w.
2021 Raspa A, Carminati L, Pugliese R, Fontana F, Gelain F “Self-assembling peptide hydrogels for the stabilization and sustained release of active Chondroitinase ABC in vitro and in spinal cord injuries” Journal of Controlled Release 330: 1208-1219 doi: 10.1016/j.jconrel.2020.11.027.
2020 Raspa A, Gelain F “Mimicking extracellular matrix via engineered nanostructured biomaterials for neural repair” Current Neuropharmacology 19 (12), 2110-2124. doi: 10.2174/ 1570159X18666201111111102.
2020 Gelain F, Zhongli L, Zhang S "Self-assembling Peptide EAK16 and RADA16 Nanofiber Scaffold Hydrogel” Chemical Reviews 120 (24): 13434-13460. doi: 10.1021/acs.chemrev.0c00690
2020 Lau CYJ, Fontana F, Mandemaker L, Wezendonk D, Vermeer B, Bonvin A, Vries R, Zhang H, Remaut K, Dikkenberg J, Medeiros-Silva J, Hassan A, Perrone B, Kuemmerle R, Gelain F, Hennink W, Weingarth M, Mastrobattista E “Control over the fibrillization yield by varying the oligomeric nucleation propensities of self-assembling peptides” Communications Chemistry 3 (1): 1-10. doi: 10.1038/s42004-020-00417-7
2020 Pugliese R, Moretti L, Maiuri M, Romanazzi T, Cerullo G, Gelain F “Superior Mechanical and Optical Properties of a Heterogeneous Library of Cross-Linked Biomimetic Self-Assembling Peptides” Materials & Design 194 doi: 10.1016/j.matdes.2020.108901
2020 Pugliese R, Gelain F “Cross-linked Self-Assembling Peptides and Their Post-Assembly
Functionalization via One-pot and In Situ Gelation System.” International Journal of Molecular Sciences 21 (12): 1-15 doi: 10.3390/ijms21124261
2020 Marchini A, Favoino C, Gelain F “Multi-functionalized self-assembling peptides as reproducible 3D cell culture systems enabling differentiation and survival of various human neural stem cell lines.” Frontiers in Neuroscience 14: art.413 doi: 10.3389/fnins.2020.00413
2020 Dellafiora L, Pugliese R, Bollati C, Gelain F, Galaverna G, Arnoldi Anna, Lammi C “Bottom up” strategy for the identification of novel soybean peptides with ACE-inhibitory activity" Journal of Agricultural and Food Chemistry 68 (7): 2082-2090 doi: 10.1021/acs.jafc.9b07361
2020 Fontana F, Gelain F “Probing mechanical properties and failure mechanisms of fibrils of self-assembling peptides” Nanoscale Advances 2: 190-198. doi: 10.1039/c9na00621d
2020 Pugliese R, Gelain F “Characterization of Elastic, Thermo-Responsive, Self-Healable Supramolecular Hydrogel made of Self-Assembly Peptides and Guar Gum” Materials & Design 186, doi: 10.1016/j.matdes.2019.108370
2019 Jekhmane S, Prachar M, Pugliese R, Fontana F, Medeiros-Silva J, Gelain F, Weingarth M “Design parameters of tissue engineering scaffolds at atomic scale” Angewandte Chemie Int. Ed. 58: 2-11. doi: 10.1002/anie.201907880
2019 Pugliese R, Bollati C, Gelain F, Arnoldi A, Lammi C "A Supramolecular Approach to develop new Soybean and Lupin Peptide Nanogels with enhanced DPP-IV Inhibitory Activity" Journal of Agricultural and Food Chemistry 67 (13): 3615-3623. doi: 10.1021/acs.jafc.8b07264
2019 Marchini A, Raspa A, Pugliese R, Abd El Malek M, Pastori V, Lecchi M, Vescovi AL, Gelain F “Multi-functionalized hydrogels foster hNSC maturation in 3D cultures and neural regeneration in spinal cord injuries” Proc Natl Acad Sci U S A. 116 (15):7483-7492. doi: 10.1073/pnas.1818392116
2019 Lammi C, Bollati C, Gelain F, Arnoldi A, Pugliese R “Enhancement of the stability and anti-DPPIV activity of hempseed hydrolysates through self-assembling peptide-based hydrogels” Frontiers in Chemistry 6, 670. doi: 10.3389/fchem.2018.00670
2019 Pugliese R, Maleki M, Zuckermann RN, Gelain F “Self-assembling peptides cross-linked with Genipin: resilient hydrogels and self-standing electrospun scaffolds for tissue engineering applications” Biomaterials Science 7, 76-91. doi: 10.1039/C8BM00825F.
2018 Saracino G, Fontana F, Jekhmane S, Silva JM, Weingarth M, Gelain F “Elucidating self-assembling peptide aggregation via Morphoscanner: a new tool for protein-peptide structural characterization” Advanced Science 5 (8): 1800471 doi: 10.1002/advs.201800471.
2018 Raspa A, Bolla E, Cuscona C, Gelain F “Feasible stabilization of chondroitinase abc enables reduced astrogliosis in a chronic model of spinal cord injury” CNS Neuroscience & Therapeutics 25 (1): 86-100. doi: 10.1111/cns.12984.
2018 Pugliese R, Marchini A, Saracino G, Gelain F “Functionalization of self-assembling peptides for neural tissue engineering” Self-Assembling Biomaterials: Molecular Design, Characterization and Application in Biology and Medicine. Elsevier, Amsterdam, NL: 475-493. Book Chapter.
2017 Pugliese R, Fontana F, Marchini A, Gelain F “Branched peptides integrate into self-assembled nanostructures and enhance biomechanics of peptidic hydrogels” Acta Biomaterialia. 66: 258-271 doi: 10.1016/j.actbio.2017.11.026.
2017 Pugliese R, Marchini A, Saracino GA, Zuckermann RN, Gelain F “Cross-linked self-assembling peptide scaffolds” Nano Research. 11(1): 586-602. doi: 10.1007/s12274-017-1834-6.
2017 Maleki M, Natalello A, Pugliese R, Gelain F “Fabrication of nanofibrous electrospun scaffolds from a heterogeneous library of co- and self-assembling peptides” Acta Biomaterialia. 51: 268-278. doi: 10.1016/j.actbio.2017.01.038.
2017 Pugliese R and Gelain F “Peptidic biomaterials: from self-assembling to regenerative medicine” Trends in Biotechnology. 35(2): 145-158. doi: 10.1016/j.tibtech.2016.09.004.
2016 Raspa A, Marchini A, Vasita R, Maleki M, Pugliese R, Mauri M, Gelain F “A biocompatibility study of new nanofibrous scaffolds for nervous regeneration” Nanoscale 8(1): 253-265. doi: 10.1039/c5nr03698d.
2016 Raspa A, Pugliese R, Maleki M, Gelain F “Recent therapeutic approaches for spinal cord injury” Biotechnology & Bioengineering 113(2): 253-259. doi: 10.1002/bit.25689.
2014 Bradshaw M, Ho D, Fear MW, Gelain F, Wood FM, Iyer KS “Designer self-assembling hydrogel scaffolds can impact skin cell proliferation and migration.” Scientific Reports 4:6903 doi: 10.1038/srep06903.
2014 Raspa A, Saracino G, Pugliese R, Silva D, Cigognini D, Vescovi A, Gelain F “Complementary Co-Assembling Peptides: from in silico studies to in vivo application.” Advanced Functional Materials 40(24): 6317-6328. doi: 10.1002/adfm.201400956.
2014 Cigognini D, Silva D, Paloppi S, Gelain F “Evaluation of mechanical properties and therapeutic effect of injectable self-assembling hydrogels for spinal cord injury.” Journal of Biomedical Nanotechnology 10(2): 309-323. doi: 10.1166/jbn.2014.1759.
2013 Saracino G and Gelain F “Modeling and analysis of early aggregation events of BMHP1-derived self-assembling peptides.” Journal of Biomolecular Structure & Dynamics 32(5): 759-775. doi: 10.1080/07391102.2013.790848.
2013 Caprini A, Silva D, Zanoni I, Cunha C, Volontè C, Vescovi A, Gelain F “A Novel Bioactive Peptide: Assessing its Activity Over Murine Neural Stem Cells and its Potential for Neural Tissue Engineering.” New Biotechnology 30(5): 552-562. doi: 10.1016/j.nbt.2013.03.005.
2013 Cunha C, Panseri S, Gelain F. Engineering of a 3D Nanostructured Scaffold Made of Functionalized Self-Assembling Peptides and Encapsulated Neural Stem Cells. Methods in Molecular Biology. 2013 Clifton, NJ: Book Chapter doi: 10.1007/7651_2012_2.
2013 Vasita R, Gelain F. “Core-sheath Fibres for Regenerative Medicine” Nanomaterials in Drug Delivery, Imaging, and Tissue Engineering. Wiley-Scrivener Publishing, Beverly: 493-533. Book Chapter.
2013 Silva D, Natalello A, Sanii B, Vasita R, Saracino GAA, Zuckermann RN, Doglia SM, Gelain F “Synthesis and Characterization of Designed BMHP1-Derived Self-Assembling Peptides for tissue engineering applications.” Nanoscale 5(2):704-718. doi: 10.1039/c2nr32656f.
2013 Saracino GAA, Cigognini D, Silva D, Caprini A, Gelain F “Nanomaterials design and tests for neural tissue engineering.” Chemical Society Reviews 42(1):225-262.
2012 Gelain F, Cigognini D, Caprini A, Silva D, Colleoni B, Donegá B, Antonini S, Cohen BE, Vescovi A. “New Bioactive Motifs and Their Use in Functionalized Self-Assembling Peptides for NSC Differentiation and Neural Tissue Engineering” Nanoscale 4(9):2946-2957.
2012 Zhang S, Yokoi H, Gelain F, Horii A “Designer Self-Assembling Peptide Nanofiber Scaffolds” Nanotechnology for Biology and Medicine: At the Building Block Level, Springer Science/Business Media Press, New York City: 123-147. Book Chapter
2011 Cigognini D, Satta A, Colleoni B, Silva D, Donega’ M, Antonini S, Gelain F “Evaluation of Early and Late Effects into the Acute Spinal Cord Injury of an Injectable Functionalized Self-assembling Scaffold”. PLoS ONE 6(5):1-15.
2011 Cunha C, Panseri S, Villa O, Silva D, Gelain F “3D culture of adult mouse neural stem cells within different functionalized self-assembling peptide scaffolds” International Journal of Nanomedicine 6: 943-955.
2011 Gelain F, Silva D, Caprini A, Villa O, Taraballi F, Natalello A, Nam KT, Doglia SM, Vescovi A “BMHP1-derived self-assembling peptides: hierarchically assembled structures with self-healing propensity and potential for tissue engineering applications.” ACS Nano 5(3):1845-59.
2011 Gelain F, Panseri S, Antonini S, Cunha C, Donega M, Lowery J, Taraballi F, Cerri G, Montagna M, Baldissera F, Vescovi A “Transplantation of nanostructured composite scaffolds neuro-prosthetics results in tissue reconstruction, axonal regeneration and neurological recovery in the chronically injured rat spinal cord.” ACS Nano 5(1): 227-236.
2010 Gelain F, Unsworth L, Zhang S “Slow and sustained release of active cytokines from self-assembling peptide scaffolds” Journal of Controlled Release 145(3):231-239.
2010 Taraballi F, Natalello A, Campione M, Doglia SM, Paleari A, Gelain F “Glycine-spacers influence over functional motif exposure and self-assembling propensity of functionalized peptides” Frontiers in Neuroengineering 3:1-9.
2009 Antonini S, Vescovi A, Gelain F “Stem cells and biomaterials: the tissue engineering approach” Stem Cells & Regenerative Medicine, Springer/Humana Press, New York City. Book Chapter
2009 Gelain F, Wang X, Horii A, Hucknall A, Koutsopoulos S, Zhang S “Designer self-assembling peptides scaffolds for 3-dimensional tissue cell cultures” Methods in Bioengineering, Artech House Press, Boston: 59-81. Book Chapter
2009 Lowery J, Panseri S, Cunha C, Gelain F “Electrospinning for Tissue Engineering Applications” Electrospun Nanofibers Research: Recent Developments, NOVA Science Publishers, Hauppauge.: 1-18. Book Chapter